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Background: contrast ultrasound allows a perfect depiction of vessels and has shown an improvement in diagnostic accuracy for lesion characterization. Using quantitative parametric curve analysis, perfusion patterns showed to be correlated to lesion malignancy. However, the assessment of perfusion has always been performed by assuming a linear relationship between video intensity and concentration...
The second harmonic imaging mode has been adapted to image tissue and shown considerable improvements in image quality in several applications compared to the fundamental mode. The improvements were attributed to the effects of wave distortion due to nonlinear propagation in tissue. However, imaging tissue at the second harmonic frequency only has various drawbacks. Because the energy in the second...
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