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The voltage-gated potassium channel Kv7.1 and its auxiliary subunit KCNE1 are expressed in the heart and give rise to the major repolarization current. The interaction of Kv7.1 with the single transmembrane helix of KCNE1 considerably slows channel activation and deactivation, raises single-channel conductance, and prevents slow voltage-dependent inactivation. We built a Kv7.1-KCNE1 model-structure...
Previous studies demonstrated that the purified endogenous inhibitor (NCX IF ) of the cardiac Na + /Ca 2+ exchanger (NCX1) has the capacity to modulate cardiac muscle contractility. Here, we tested the effects of purified NCX IF on arrhythmias induced by ouabain in the atria and ventricle strips of guinea pig. For the sake of comparison NCX IF was compared to...
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