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IL-33 functions as a ligand for ST2L, which is mainly expressed in immune cells, including mast cells. IL-33 is a potent inducer of pro-inflammatory cytokines, such as IL-6, and has been implicated in the pathogenesis of allergic inflammatory diseases. Therefore, IL-33 has recently been attracting attention as a new target for the treatment of inflammatory diseases. In the present study, we demonstrated...
IL-33, a member of the IL-1 family of cytokines, has been shown to activate NF-kB and MAP kinase family through the IL-1 receptor-related protein, ST2L (or IL-33R). We have previously reported that TRAF6 is a critical signal transducer in IL-33 signaling pathway, demonstrating the critical involvement of TRAF6 in IL-33-mediated p38, JNK and NF-kB activation. In addition, we found that IL-33 rapidly...
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