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Hydrolysis-resistant analogues of GTP specifically stimulate the formation of [ 3 H]inositol mono-, bis- and trisphosphates by saponin-permeabilized Swiss 3T3 cells prelabelled with [ 3 H]inositol. Each inositol phosphate is formed largely by hydrolysis of its parent lipid and not by dephosphorylation of inositol 1,4,5-trisphosphate [(1,4,5)IP 3 ]. Although hydrolysis of phosphatidylinositol...