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Resistance to Theiler's virus-induced demyelination maps genetically to the MHC class I D region and is associated with up-regulation of class I products and the presence of MHC-restricted virus-specific cytotoxic CD8 + T cells in the CNS. To determine the targets of the cytotoxic response, transfected C57SV (K b , D b ) cells expressing LP (including the leader peptide, VP4,...