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Ischemic preconditioning (IPC) protects against heart prolonged lethal ischemia by activating a cardioprotective signalling cascade involving Akt and GSK3β; however molecular pathways are still incompletely known. In an in vivo model of IPC, we previously demonstrated that the Wnt pathway can inhibit cardioprotection via a direct target, GSK3β.Here we go further in the preconditioning pathway comprehension...
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