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This study aimed at investigating the effects of genetic angiotensin-converting enzyme (ACE) 2 deficiency on glucose homeostasis in the pancreas and skeletal muscle and their reversibility following ACE inhibition.ACE2-knockout and C57bl6J mice were placed on a standard diet (SD) or a high-fat diet (HFD) for 12weeks. An additional group of ACE2-knockout mice was fed a SD and treated with the ACE inhibitor,...
This study was designed to evaluate the potential role of osteoprotegerin (OPG) in arterial fibrosis.Aortic samples were analyzed after in vivo treatment of ApoE −/− mice with recombinant human OPG. Mouse vascular smooth muscle cells (VSMC) were exposed in vitro to recombinant OPG and analyzed for markers of inflammation and fibrosis, such as fibronectin, collagen I, III, IV and transforming...
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