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Background
Prostate cancer (PC) is the most commonly diagnosed malignancy and the second leading cause of cancer‐related deaths in males. The disease is initially treated with methods that inhibit androgen receptor (AR) signal transduction. Laboratory‐based and clinical studies have identified alternative pathways that cause the failure of AR signal inhibition and consequent development of castration‐resistant...
Treatment options for metastatic renal cell carcinoma (RCC) are limited. In this study, we investigated impact of prostaglandin E2 (PGE2) receptor 4 (EP4) on RCC metastasis. We found that knockdown of EP4 in two RCC cell lines, ACHN and SN12C, does not affect xenograft tumor take or growth rate in mice, but reduces metastasis by decreasing tumor intravasation. Using chick chorioallantoic membrane...
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