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Peroxynitrite (ONOO - /ONOOH) is a powerful and relatively long-lived oxidant that causes single-strand breaks in plasmid supercoiled DNA and induces mutations. Peroxynitrite can nitrate e.g. guanosine or tyrosine. The selenium-containing compound, ebselen, reacts with peroxynitrite. Here, we studied the effect of some selenium-containing compounds such as selenomethionine and selenocystine...
Peroxynitrite (ONOO - /ONOOH) is a powerful oxidant that can induce mutations and cause single-strand breaks in plasmid supercoiled DNA. The selenium-containing compound ebselen rapidly reacts with peroxynitrite. Therefore, ebselen [2-phenyl-1,2-benzisoselenazol-3(2H)-one] and other selenium-containing molecules, selenomethionine and selenocystine, were studied as agents protecting DNA from...
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