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IL-27 is composed of the IL-30 cytokine subunit associated to the soluble receptor EBI3. IL-30 comprises an unusual poly-glutamic (poly E) motif in the loop connecting α helix C and D. The binding of sialoprotein to hydroxyapatite, the main mineral component of bone, is mediated by a very similar motif. We analysed the functions of the poly E motif using alanine substitutions. We observed that IL-27...
The central nervous system is an important target for manganese (Mn) intoxication in humans; it may cause neurological symptoms similar to Parkinson's disease. Manganese compounds emitted from the tailpipe of vehicles using methylcyclopentadienyl manganese tricarbonyl (MMT) are primarily Mn phosphate, Mn sulfate, and Mn phosphate/sulfate mixture. The purpose of this study is to compare the patterns...
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