Search results for: Christopher Newton-Cheh

Items from 1 to 20 out of 51 results

article

Should Identifying a Titin Truncating Variant Change the Management of Patients With Dilated Cardiomyopathy?∗

Christopher Newton-Cheh

Journal of the American College of Cardiology > 2017 > 70 > 18 > 2275-2277

article

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

G. Todd Milne, on behalf of the Ironwood team, Peter Sandner, Kathleen A. Lincoln, more

BMC Pharmacology and Toxicology > 2017 > 18 > 1 > 1-35

article

The genetic component of bicuspid aortic valve and aortic dilation. An exome-wide association study

Marina Gago-Díaz, María Brion, Pastora Gallego, Francisco Calvo, more

Journal of Molecular and Cellular Cardiology > 2017 > 102 > C > 3-9

Bicuspid aortic valve is the most common cardiovascular congenital malformation affecting 2% of the general population. The incidence of life-threatening complications, the high heritability, and familial clustering rates support the interest in identifying risk or protective genetic factors. The main objective of the present study was to identify population-based genetic variation associated with...

article

52 Genetic Loci Influencing Myocardial Mass

Pim van der Harst, Jessica van Setten, Niek Verweij, Georg Vogler, more

Journal of the American College of Cardiology > 2016 > 68 > 13 > 1435-1448

Myocardial mass is a key determinant of cardiac muscle function and hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the amplitude and duration of the QRS complex on the electrocardiogram (ECG). Abnormal QRS amplitude or duration reflect changes in myocardial mass and conduction, and are associated with increased risk of heart failure and death.This meta-analysis...

article

Acute Metabolic Influences on the Natriuretic Peptide System in Humans

Pankaj Arora, Connie Wu, Tariq Hamid, Garima Arora, more

Journal of the American College of Cardiology > 2016 > 67 > 7 > 804-812

The cardiac natriuretic peptides (NPs), atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), have central roles in sodium and blood pressure regulation. Extracardiac factors (e.g., obesity and diabetes) influence NP production, potentially altering cardiovascular responses to volume and pressure stress.This study examined the effects of acute carbohydrate intake on the NP system...

article

50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study

Renate B Schnabel, Xiaoyan Yin, Philimon Gona, Martin G Larson, more

The Lancet > 2015 > 386 > 9989 > 154-162

Comprehensive long-term data on atrial fibrillation trends in men and women are scant. We aimed to provide such data through analysis of the Framingham cohort over 50 years. We investigated trends in incidence, prevalence, and risk factors for atrial fibrillation and its association with stroke and mortality after onset in 9511 participants enrolled in the Framingham Heart Study between 1958 and...

article

Genome-wide association studies of late-onset cardiovascular disease

J.Gustav Smith, Christopher Newton-Cheh

Journal of Molecular and Cellular Cardiology > 2015 > 83 > Complete > 131-141

Human genetics is a powerful tool for discovering causal mediators of human disease and physiology. Cardiovascular diseases with late onset in the lifecourse have historically not been considered genetic diseases, but in recent years the contribution of a heritable factor has been established. More importantly, over the last decade genome-wide association studies (GWASs) have identified many loci...

article

ACUTE METABOLIC INFLUENCES ON THE NATRIURETIC PEPTIDE SYSTEM IN HUMANS

Pankaj Arora, Connie Wu, Tariq Hamid, Garima Arora, more

Journal of the American College of Cardiology > 2015 > 65 > 10(S) > A2144

article

Effects of Long-Term Averaging of Quantitative Blood Pressure Traits on the Detection of Genetic Associations

Christopher Newton-Cheh, Toby Johnson, Vesela Gateva, Martin D. Tobin, more

The American Journal of Human Genetics > 2014 > 95 > 1 > 49-65

article

An Enhancer Polymorphism at the Cardiomyocyte Intercalated Disc Protein NOS1AP Locus Is a Major Regulator of the QT Interval

Ashish Kapoor, Rajesh B. Sekar, Nancy F. Hansen, Karen Fox-Talbot, more

The American Journal of Human Genetics > 2014 > 94 > 6 > 854-869

QT interval variation is assumed to arise from variation in repolarization as evidenced from rare Na- and K-channel mutations in Mendelian QT prolongation syndromes. However, in the general population, common noncoding variants at a chromosome 1q locus are the most common genetic regulators of QT interval variation. In this study, we use multiple human genetic, molecular genetic, and cellular assays...

article

Sa1779 Vitamin D Modulates T Cell-Mediated Immunity: Results From a Randomized Controlled Trial of Low-Dose and High-Dose Vitamin D3

Gauree G. Konijeti, Matthew R. Boylan, Yanna Song, Pankaj Arora, more

Gastroenterology > 2014 > 146 > 5 Supplement 1 > S-294

article

WEIGHT LOSS, SALINE LOADING, AND THE NATRIURETIC PEPTIDE SYSTEM

Pankaj Arora, Jason Reingold, Aaron Baggish, Derek Guanaga, more

Journal of the American College of Cardiology > 2014 > 63 > 12(S) > A1354

article

Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci

Vinicius Tragante, Michael R. Barnes, Santhi K. Ganesh, Matthew B. Lanktree, more

The American Journal of Human Genetics > 2014 > 94 > 3 > 349-360

Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ∼50,000 SNPs in up to 87,736 individuals of European ancestry and combined these in a meta-analysis. We replicated findings in an independent set of 68,368 individuals of European...

article

Gene-environment interaction between SCN5A-1103Y and hypokalemia influences QT interval prolongation in African Americans: The Jackson Heart Study

Ermeg L. Akylbekova, John P. Payne, Christopher Newton-Cheh, Warren L. May, more

American Heart Journal > 2014 > 167 > 1 > 116-122.e1

African-American ancestry, hypokalemia, and QT interval prolongation on the electrocardiogram are all risk factors for sudden cardiac death (SCD), but their interactions remain to be characterized. SCN5A-1103Y is a common missense variant, of African ancestry, of the cardiac sodium channel gene. SCN5A-1103Y is known to interact with QT-prolonging factors to promote ventricular arrhythmias in persons...

article

A common missense variant in the neuregulin 1 gene is associated with both schizophrenia and sudden cardiac death

Adriana Huertas-Vazquez, Carmen Teodorescu, Kyndaron Reinier, Audrey Uy-Evanado, more

Heart Rhythm > 2013 > 10 > 7 > 994-998

Both schizophrenia and epilepsy have been linked to increased risk of sudden cardiac death (SCD). We hypothesized that DNA variants within genes previously associated with schizophrenia and epilepsy may contribute to an increased risk of SCD.To investigate the contribution to SCD susceptibility of DNA variants previously implicated in schizophrenia and epilepsy.From the ongoing Oregon Sudden Unexpected...

article

Development and application of a longitudinal electrocardiogram repository: the Framingham Heart Study

Jared W. Magnani, Christopher Newton-Cheh, Christopher J. O'Donnell, Daniel Levy

Journal of Electrocardiology > 2012 > 45 > 6 > 673-676

The electrocardiogram (ECG) has widespread use in clinical care and research. Despite its extensive use and study, important gaps remain in examining prospective, repeated longitudinal ECG measures, and their association with cardiovascular outcomes. The Framingham Heart Study (FHS) is a community-based study designed to examine risk factors and outcomes associated with cardiovascular disease. Here,...

article

QT Interval and Long‐Term Mortality Risk in the Framingham Heart Study

Peter A. Noseworthy, Gina M. Peloso, Shih‐Jen Hwang, Martin G. Larson, more

Annals of Noninvasive Electrocardiology > 17 > 4 > 340 - 348

Background: The association between QT interval and mortality has been demonstrated in large, prospective population‐based studies, but the strength of the association varies considerably based on the method of heart rate correction. We examined the QT‐mortality relationship in the Framingham Heart Study (FHS). Methods: Participants in the first (original cohort, n = 2,365) and second generation (offspring...

article

A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern

Moritz F. Sinner, Kimmo Porthan, Peter A. Noseworthy, Aki S. Havulinna, more

Heart Rhythm > 2012 > 9 > 10 > 1627-1634

The early repolarization pattern (ERP) is common and associated with risk of sudden cardiac death. ERP is heritable, and mutations have been described in syndromatic cases. To conduct a meta-analysis of genome-wide association studies to identify common genetic variants influencing ERP. We ascertained ERP on the basis of electrocardiograms in 3 large community-based cohorts from Europe and the...

article

Burden of Rare Sarcomere Gene Variants in the Framingham and Jackson Heart Study Cohorts

Alexander G. Bick, Jason Flannick, Kaoru Ito, Susan Cheng, more

The American Journal of Human Genetics > 2012 > 91 > 3 > 513-519

Rare sarcomere protein variants cause dominant hypertrophic and dilated cardiomyopathies. To evaluate whether allelic variants in eight sarcomere genes are associated with cardiac morphology and function in the community, we sequenced 3,600 individuals from the Framingham Heart Study (FHS) and Jackson Heart Study (JHS) cohorts. Out of the total, 11.2% of individuals had one or more rare nonsynonymous...

article

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

Benjamin F Voight, Gina M Peloso, Marju Orho-Melander, Ruth Frikke-Schmidt, more

The Lancet > 2012 > 380 > 9841 > 572-580

High plasma HDL cholesterol is associated with reduced risk of myocardial infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are randomly assigned at meiosis, are independent of non-genetic confounding, and are unmodified by disease processes, mendelian randomisation can be used to test the hypothesis that the association of a plasma biomarker with disease...

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Search results for: Christopher Newton-Cheh

Should Identifying a Titin Truncating Variant Change the Management of Patients With Dilated Cardiomyopathy?∗

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

The genetic component of bicuspid aortic valve and aortic dilation. An exome-wide association study

52 Genetic Loci Influencing Myocardial Mass

Acute Metabolic Influences on the Natriuretic Peptide System in Humans

50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study

Genome-wide association studies of late-onset cardiovascular disease

ACUTE METABOLIC INFLUENCES ON THE NATRIURETIC PEPTIDE SYSTEM IN HUMANS

Effects of Long-Term Averaging of Quantitative Blood Pressure Traits on the Detection of Genetic Associations

An Enhancer Polymorphism at the Cardiomyocyte Intercalated Disc Protein NOS1AP Locus Is a Major Regulator of the QT Interval

Sa1779 Vitamin D Modulates T Cell-Mediated Immunity: Results From a Randomized Controlled Trial of Low-Dose and High-Dose Vitamin D3

WEIGHT LOSS, SALINE LOADING, AND THE NATRIURETIC PEPTIDE SYSTEM

Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci

Gene-environment interaction between SCN5A-1103Y and hypokalemia influences QT interval prolongation in African Americans: The Jackson Heart Study

A common missense variant in the neuregulin 1 gene is associated with both schizophrenia and sudden cardiac death

Development and application of a longitudinal electrocardiogram repository: the Framingham Heart Study

QT Interval and Long‐Term Mortality Risk in the Framingham Heart Study

A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern

Burden of Rare Sarcomere Gene Variants in the Framingham and Jackson Heart Study Cohorts

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

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