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ProblemThe pregnancy‐associated disease preeclampsia is related to the release of syncytiotrophoblast extracellular vesicles (STBEV) by the placenta. To improve functional research on STBEV, reliable and specific methods are needed to quantify them. However, only a few quantification methods are available and accepted, though imperfect. For this purpose, we aimed to provide an enzyme‐linked sorbent...
Trophoblast progenitor cells express stem cells markers (SCM) to maintain the proliferative characteristic of stem cells. Beyond blastocyst stage or in preeclampsia (PE) or intrauterine growth restriction (IUGR) little is known about expression of SCMs. We examined the expression of trophoblast and other SCMs in 1st and 3rd trimester placenta and in preeclampsia (PE) and intrauterine growth restriction...
Endothelial dysfunction is thought to be the cause of preeclampsia (PE) symptoms. Severe forms of PE are correlated to the release of syncytiotrophoblastic microparticles (STBM), which triggers inflammatory processes on the endothelium. The thrombogenic potential of STBMs is not well characterized. We investigated the pro-coagulant activity of STBMs.STBMs were derived from placentae perfused under...
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