Search results for: O. Goureau

Items from 1 to 12 out of 12 results

article

Chronic exposure to TNFα impairs RPE barrier and immunosuppressive functions

S. Touhami, F. Beguier, S. Augustin, S. Reichman, more

Acta Ophthalmologica > 95 > S259 > n/a - n/a

Purpose The retinal pigment epithelium (RPE) is a monolayer of pigmented cells with important roles in the outer blood‐retinal barrier and subretinal immune suppression. Failure of RPE functions and inflammation have both been hypothesized to play a role in the pathophysiology of age related macular degeneration (AMD). We here investigated the long‐term effects of TNFα on RPE morphology and function...

article

The protein tyrosine phosphatase interacting protein 51 (PTPIP51) is required for the differentiation of photoreceptors

G. Orieux, A. Slembrouck, M. Bensaïd, J.-A. Sahel, more

Neuroscience > 2015 > 300 > Complete > 276-285

Proliferation and differentiation of retinal progenitor cells (RPCs) are tightly controlled by extrinsic cues and distinct combinations of transcription factors leading to the generation of retinal cell type diversity. In this context, we investigated the role of the protein tyrosine phosphatase interacting protein 51 (PTPIP51) in the differentiation of RPCs. The expression pattern of PTPIP51 was...

article

Pluripotent stem cells (ES & iPS) for treatment of retinal dystrophies

O GOUREAU

Acta Ophthalmologica > 91 > s252 > 0 - 0

The impaired or complete loss of function of photoreceptor cells or supporting retinal pigmented epithelium (RPE) is the main cause of irreversible blindness in retinal diseases, such as inherited retinal degenerations and age‐related macular degeneration (AMD). Rescuing the degenerated retina is a major challenge and cell replacement is one of the most promising approaches with the use of pluripotent...

article

Ptf1a/Rbpj complex inhibits ganglion cell fate and drives the specification of all horizontal cell subtypes in the chick retina

E.C. Lelièvre, M. Lek, H. Boije, L. Houille-Vernes, more

Developmental Biology > 2011 > 358 > 2 > 296-308

During development, progenitor cells of the retina give rise to six principal classes of neurons and the Müller glial cells found within the adult retina. The pancreas transcription factor 1 subunit a (Ptf1a) encodes a basic-helix–loop–helix transcription factor necessary for the specification of horizontal cells and the majority of amacrine cell subtypes in the mouse retina. The Ptf1a-regulated genes...

article

Cellules souches rétiniennes : mécanisme de différenciation et potentiel thérapeutique

O. Goureau, J.-A. Sahel

Pathologie Biologie > 2006 > 54 > 2 > 64-71

Parmi les approches thérapeutiques permettant de retarder ou de prévenir la perte visuelle, la visée restauratrice se fondant sur la régénération ou le remplacement cellulaire est de moins en moins utopique. L'émergence de travaux démontrant la possibilité de renouvellement cellulaire dans le système nerveux central adulte, dont la rétine, permet d'envisager l'implantation de cellules souches ou progénitrices...

article

DNA repair in the degenerating mouse retina

L. Menu dit Huart, O. Lorentz, O. Goureau, T. Léveillard, more

Molecular and Cellular Neuroscience > 2004 > 26 > 3 > 441-449

In light of different recent results suggesting that the adult mammalian central nervous system can produce new neurons, possibly as an endogenous repair mechanism, we investigated whether neurogenesis occurs in response to photoreceptor degeneration in the rd1 mouse, a model of human-inherited retinal dystrophy. Bromodeoxy-Uridine (BrdU) incorporation and proliferating cell nuclear antigen (PCNA)...

article

Delayed onset and decreased severity of experimental autoimmune uveoretinitis in mice lacking nitric oxide synthase type 2

B Thillaye-Goldenberg, O Goureau, M.C Naud, Y de Kozak

Journal of Neuroimmunology > 2000 > 110 > 1-2 > 31-44

To investigate the role of nitric oxide (NO), produced by the inducible form of NO synthase (NOS-2) in the development of experimental autoimmune uveoretinitis (EAU), we immunized C57BL/6×129Sv (H-2 ^b ) mice carrying a targeted disruption of the gene encoding NOS-2 (NOS-2[−/−]), and wild-type (WT) C57BL/6×129Sv controls with interphotoreceptor retinoid binding protein (IRBP). NOS-2[−/−] mice...

article

Nitric Oxide in the Eye: Multifaceted Roles and Diverse Outcomes

F. Becquet, Y. Courtois, O. Goureau

Survey of Ophthalmology > 1997 > 42 > 1 > 71-82

Recent works have highlighted the role of nitric oxide in a wide array of disease entities, including septic shock, hypertension, cerebral ischemia, and chronic degenerative diseases of the nervous system. The functions of nitric oxide appear very diverse, having actions on vascular tone, neurotransmission, immune cytotoxicity, and many others. Nitric oxide is an important mediator of homeostatic...

article

Effects of intraocular injection of no donnors in the rabbit

F. Behar-Cohen, O. Goureau, F. D'Hermie, Y. Courtois

Vision Research > 1995 > 35 > Supplement 1; Supplement > S62

Purpose: Nitric Oxyde (NO) is synthesized by two types of NO synthases: A constitutive isoforme (cNOS) which activity is calcium-calmodulin dependent, and an inducible one (iNOS), regulated by cytokines and stimulated by lipopolysacharide (LPS). NOSc activity has been demonstrated in the ciliary body, in the choroid, and in the retina (amacrines cells, RPE and ROS). NO could be implicated in the...

article

Effects of intraocular injection of no donnors in the rabbit.

F. Behar-Cohen, O. Goureau, F. D'Hermie, Y. Courtois

Vision Research > 1995 > 35 > Supplement 1; Supplement > S191

article

Role of immunoregulatory cytokines TGF-β, IL-4, IL-10, in the in vitro production of TNF and no by retinal resident cells

Y de Kozak, MC Naud, O Goureau, Y Courtois, more

Vision Research > 1995 > 35 > Supplement 1; Supplement > S114

Purpose: We have previously shown that cultured retinal M:ller glia (RMG) and retinal pigmented epithelium (RPE) isolated from Lewis rat and stimulated by lipopolysaccharide (LPS) and interferon (IFN)-γ release large amounts of tumor necrosis factor (TNF) and nitric oxide (NO). Ocular models of inflammation (S-antigen-induced experimental autoimmune uveoretinitis, EAU and endotoxin-induced uveitis,...

article

Fibroblast growth factors alter light responses and dark voltage in retinal rods of the frog (Rana temporaria)

K.-F. Schmidt, M. Billek, C. Pietruck, G.N. Nöll, more

Neuroscience Letters > 1995 > 191 > 3 > 177-180

Fibroblast growth factors (FGF-1 and FGF-2) were applied intracellularly via whole-cell patch-clamp electrodes while the membrane voltage was recorded simultaneously. During recording the exchange of substances by diffusion between cytosol and pipette medium affects the cell's function. Under control conditions, the loss of nucleotides is reflected by a slow hyperpolarization of the dark voltage...

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