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Cerebrospinal fluid (CSF) tau, tau phosphorylated at threonine 181 (ptau), and Aβ 42 are established biomarkers for Alzheimer’s disease (AD) and have been used as quantitative traits for genetic analyses. We performed the largest genome-wide association study for cerebrospinal fluid (CSF) tau/ptau levels published to date (n = 1,269), identifying three genome-wide significant loci for CSF...
Olfactory neurons obtained through nasal biopsy were characterized. Using standard immunohistochemical techniques, nascent, developing, and mature neurons were identified in the tissues obtained. This technique shows that aspects of canine olfactory function may be potentially assessed using a relatively simple and minimally invasive biopsy technique. Such samples provide direct access to neuronal...
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