G. William MacEwan

article

Clinical and functional characteristics of young adults living in single room occupancy housing: preliminary findings from a 10-year longitudinal study

Skye P. Barbic, Andrea A. Jones, Melissa Woodward, Matt Piercy, more

Canadian Journal of Public Health > 2018 > 109 > 2 > 204-214

Objective Young adults living in single room occupancy (SRO) hotels, a form of low-income housing, are known to have complex health and substance problems compared to their peers in the general population. The objective of this study is to comprehensively describe the mental, physical, and social health profile of young adults living in SROs. Methods This study reports baseline data from young adults...

article

A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence

Peter D Alexander, Kristina M Gicas, Taylor S Willi, Clara N Kim, more

Psychopharmacology > 2017 > 234 > 9-10 > 1535-1547

Rationale The psychostimulant drugs cocaine and methamphetamine are potent indirect dopamine receptor agonists which act through similar but not identical mechanisms. Studies in humans have observed that a large proportion of those who chronically use these drugs experience psychotic symptoms. However, direct comparisons of psychotic symptom severity between cocaine and methamphetamine users are lacking...

article

Subcortical grey matter alterations in cocaine dependent individuals with substance-induced psychosis compared to non-psychotic cocaine users

Taylor S. Willi, Donna J. Lang, William G. Honer, Geoff N. Smith, more

Schizophrenia Research > 2016 > 176 > 2-3 > 158-163

After prolonged psychostimulant abuse, transient psychotic symptoms referred to as “substance-induced psychosis” (SIP) can develop – closely resembling symptoms observed in schizophrenia spectrum disorders. The comparability in psychotic presentation between SIP and schizophrenias suggests that similar underlying neural deficits may contribute to the expression of psychosis across these disorders...

article

Factors affecting severity of positive and negative symptoms of psychosis in a polysubstance using population with psychostimulant dependence

Taylor S. Willi, William G. Honer, Allen E. Thornton, Kristina Gicas, more

Psychiatry Research > 2016 > 240 > C > 336-342

Approximately half of psychostimulant users experience psychotic symptoms, which include both positive and negative symptoms. Prior reports have exclusively used positive symptoms to characterize psychostimulant associated psychosis. Symptoms vary dramatically in severity, though most investigations categorize psychosis as a dichotomous occurrence. To explore the association between different substances...

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White matter deficits assessed by diffusion tensor imaging and cognitive dysfunction in psychostimulant users with comorbid human immunodeficiency virus infection

Victor M. Tang, Donna J. Lang, Chantelle J. Giesbrecht, William J. Panenka, more

BMC Research Notes > 2015 > 8 > 1 > 1-15

Background Psychostimulant drug use is commonly associated with drug-related infection, including the human immunodeficiency virus (HIV). Both psychostimulant use and HIV infection are known to damage brain white matter and impair cognition. To date, no study has examined white matter integrity using magnetic resonance imaging (MRI) diffusion tensor imaging (DTI) in chronic psychostimulant users with...

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48 echo T2 myelin imaging of white matter in first-episode schizophrenia: Evidence for aberrant myelination

Donna J.M. Lang, Eugene Yip, Alexander L. MacKay, Allen E. Thornton, more

NeuroImage: Clinical > 2014 > 6 > Complete > 408-414

Myelin water imaging provides a novel strategy to assess myelin integrity and corresponding clinical relationships in psychosis, of particular relevance in frontal white matter regions. In the current study, T ₂ myelin water imaging was used to assess the myelin water fraction (MWF) signal from frontal areas in a sample of 58 individuals experiencing first-episode psychosis (FEP) and 44 healthy...

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Effects of eight weeks of atypical antipsychotic treatment on middle frontal thickness in drug-naïve first-episode psychosis patients

Vina M. Goghari, Geoffrey N. Smith, William G. Honer, Lili C. Kopala, more

Schizophrenia Research > 2013 > 149 > 1-3 > 149-155

Atypical antipsychotic medications generally maintain or increase gray matter amount and functioning. First-episode psychosis patients have lower gray matter volume in the middle frontal gyrus, as well as worse performance on spatial working memory tasks compared to controls. This study investigated the effects of short-term four- and eight-week atypical treatment on middle frontal thickness and spatial...

article

Methamphetamine use: A comprehensive review of molecular, preclinical and clinical findings

William J. Panenka, Ric M. Procyshyn, Tania Lecomte, G. William MacEwan, more

Drug and Alcohol Dependence > 2013 > 129 > 3 > 167-179

Methamphetamine (MA) is a highly addictive psychostimulant drug that principally affects the monoamine neurotransmitter systems of the brain and results in feelings of alertness, increased energy and euphoria. The drug is particularly popular with young adults, due to its wide availability, relatively low cost, and long duration of psychoactive effects. Extended use of MA is associated with many health...

article

Poster #154 NEUROCOGNITIVE PROFILES OF MARGINALIZED PERSONS WITH COMORBID PSYCHOSIS AND POLYSUBSTANCE ABUSE

Kristina Gicas, Heather A. Baitz, Chanteile J. Giesbrecht, Fidel Vila-Rodriguez, more

Schizophrenia Research > 2012 > 136 > Supplement 1 > S146-S147

article

14:30 EFFECTS OF EIGHT WEEKS OF ATYPICAL ANTI-PSYCHOTIC MEDICATION TREATMENT ON MIDDLE FRONTAL THICKNESS IN DRUG-NAÏVE FIRST EPISODE PSYCHOSIS PATIENTS

Vina M. Goghari, Geoffrey N. Smith, William G. Honer, Lili C. Kopala, more

Schizophrenia Research > 2012 > 136 > Supplement 1 > S88

article

Hippocampal volume and the brain-derived neurotrophic factor Val66Met polymorphism in first episode psychosis

Geoffrey N. Smith, Allen E. Thornton, Donna J. Lang, G. William MacEwan, more

Schizophrenia Research > 2012 > 134 > 2-3 > 253-259

Small hippocampi and impaired memory are common in patients with psychosis and brain-derived neurotrophic factor (BDNF) plays a critical role in hippocampal neuroplasticity and memory. A common BDNF allele (Val66Met) has been the focus of numerous studies but results from the few BDNF-imaging studies are complex and contradictory. The objective of this study was to determine the association between...

article

First episode psychosis with extrapyramidal signs prior to antipsychotic drug treatment

William G. Honer, Donna J. Lang, Lili C. Kopala, G. William Macewan, more

Chinese Science Bulletin > 2011 > 56 > 32 > 3361-3371

Extrapyramidal movement disorders are common in chronic schizophrenia, and may be an intrinsic feature of the illness as well as related to antipsychotic drug treatment. Similar dysfunctions at illness onset may have implications for outcome, and for understanding the mechanisms of illness. The objectives were to examine the clinical correlates of pre-treatment movement disorders at first episode...

article

Prenatal tobacco exposure in first-episode psychosis

Geoffrey N. Smith, G. William MacEwan, Lili C. Kopala, Thomas S. Ehmann, more

Schizophrenia Research > 2010 > 119 > 1-3 > 271-272

article

A DOUBLE BLIND, PLACEBO CONTROLLED STUDY OF THE SAFETY AND TOLERABILITY OF QUETIAPINE 1200 MG/D VERSUS 800 MG/D IN PATIENTS WITH PERSISTENT SYMPTOMS OF SCHIZOPHRENIA OR SCHIZOAFFECTIVE DISORDER

William G. Honer, G. William MacEwan, Alain Gendron, Emmanuel Stip, more

Schizophrenia Research > 2010 > 117 > 2-3 > 375

article

SOCIAL NETWORK CHARACTERISTICS AND EFFECT ON SEVERITY OF PSYCHOSIS IN A COMMUNITY SAMPLE WITH HIGH PREVALENCE OF STIMULANT USE

Willough A. Jenkins, Fidel Vila-Rodriguez, Karine Paquet, G. William MacEwan, more

Schizophrenia Research > 2010 > 117 > 2-3 > 190-191

article

A COMPARISON TO CONTROLS OF BRAIN STRUCTURE IN SUBJECTS WITH METHAMPHETAMINE PSYCHOSIS AND COMORBID HIV INFECTION

Alasdair M. Barr, William G. Honer, G. William MacEwan, Willough Jenkins, more

Schizophrenia Research > 2010 > 117 > 2-3 > 222

article

Predictors of starting to smoke cigarettes in patients with first episode psychosis

Geoffrey N. Smith, Hubert Wong, G. William MacEwan, Lili C. Kopala, more

Schizophrenia Research > 2009 > 108 > 1-3 > 258-264

Cigarette smoking is common in psychotic disorders and may be initiated in an attempt to control features of illness. However, genetic, obstetric and early life conditions are risks for starting to smoke in the general population but their role in psychotic patients is unclear.Smoking history and the putative predictors of starting to smoke were assessed in a community-wide sample of 115 first episode...

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Predictors and profiles of treatment non-adherence and engagement in services problems in early psychosis

Tania Lecomte, Alicia Spidel, Claude Leclerc, G. William MacEwan, more

Schizophrenia Research > 2008 > 102 > 1-3 > 295-302

Treatment adherence in early psychosis individuals is considered problematic. Some studies have tried to understand reasons for medication non-adherence in this population, though few have also considered engagement in services. We conducted a cross-sectional study with 118 early psychosis individuals, assessing multiple constructs (symptoms, insight, personality traits, alliance, childhood trauma,...

article

MAG Gene Variation and Cortical Gray Matter Volume in First Episode Schizophrenia

Aristotle N. Voineskos, Donna J. Lang, Gwyneth Zai, Natalie Bulgin, more

Brain Imaging and Behavior > 2008 > 2 > 2 > 117-122

Evidence implicating myelin related genes in the pathophysiology of schizophrenia is accumulating. Abnormalities of brain structure at the onset of psychosis may be related to variation in genes such as myelin associated glycoprotein (MAG). Subjects with first episode schizophrenia (n = 30) or schizoaffective disorder (n = 11), and healthy comparison subjects (n = 43) participated in an MRI scan....

article

An open trial of risperidone augmentation of partial response to clozapine

Christine G. Taylor, Sean W. Flynn, Siemion Altman, Tom Ehmann, more

Schizophrenia Research > 2001 > 48 > 1 > 156-158

INFONA - science communication portal

Search results for: G. William MacEwan

Clinical and functional characteristics of young adults living in single room occupancy housing: preliminary findings from a 10-year longitudinal study

A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence

Subcortical grey matter alterations in cocaine dependent individuals with substance-induced psychosis compared to non-psychotic cocaine users

Factors affecting severity of positive and negative symptoms of psychosis in a polysubstance using population with psychostimulant dependence

White matter deficits assessed by diffusion tensor imaging and cognitive dysfunction in psychostimulant users with comorbid human immunodeficiency virus infection

48 echo T2 myelin imaging of white matter in first-episode schizophrenia: Evidence for aberrant myelination

Effects of eight weeks of atypical antipsychotic treatment on middle frontal thickness in drug-naïve first-episode psychosis patients

Methamphetamine use: A comprehensive review of molecular, preclinical and clinical findings

Poster #154 NEUROCOGNITIVE PROFILES OF MARGINALIZED PERSONS WITH COMORBID PSYCHOSIS AND POLYSUBSTANCE ABUSE

14:30 EFFECTS OF EIGHT WEEKS OF ATYPICAL ANTI-PSYCHOTIC MEDICATION TREATMENT ON MIDDLE FRONTAL THICKNESS IN DRUG-NAÏVE FIRST EPISODE PSYCHOSIS PATIENTS

Hippocampal volume and the brain-derived neurotrophic factor Val66Met polymorphism in first episode psychosis

First episode psychosis with extrapyramidal signs prior to antipsychotic drug treatment

Prenatal tobacco exposure in first-episode psychosis

A DOUBLE BLIND, PLACEBO CONTROLLED STUDY OF THE SAFETY AND TOLERABILITY OF QUETIAPINE 1200 MG/D VERSUS 800 MG/D IN PATIENTS WITH PERSISTENT SYMPTOMS OF SCHIZOPHRENIA OR SCHIZOAFFECTIVE DISORDER

SOCIAL NETWORK CHARACTERISTICS AND EFFECT ON SEVERITY OF PSYCHOSIS IN A COMMUNITY SAMPLE WITH HIGH PREVALENCE OF STIMULANT USE

A COMPARISON TO CONTROLS OF BRAIN STRUCTURE IN SUBJECTS WITH METHAMPHETAMINE PSYCHOSIS AND COMORBID HIV INFECTION

Predictors of starting to smoke cigarettes in patients with first episode psychosis

Predictors and profiles of treatment non-adherence and engagement in services problems in early psychosis

MAG Gene Variation and Cortical Gray Matter Volume in First Episode Schizophrenia

An open trial of risperidone augmentation of partial response to clozapine

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