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To evaluate the pharmacokinetics of ethanol in the early second trimester of pregnancy, ethanol concentrations simultaneously measured in the maternal blood (EtOH-MB) and in the amniotic fluid (EtOH-AF) of six pregnant women were obtained from a previous study in which a single ethanol dose of 300mgkg -1 body weight was administered orally. For maternal blood ethanol concentration, the...
Using a mathematical approach, we analyzed the behavior of the PD model originally described by Bragg et al. The effect was dose-dependent modified until a maximum value (E max ) was reached. Further increments in dose prolonged the E max , but the recovery phase did not increase beyond a calculable asymptope. In the absence of plasma concentrations, it was impossible...
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