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A putative S-adenosylmethionine synthetase (SAM-s) gene from Streptomyces avermitilis NRRL8165 was cloned and characterized. The gene encodes a protein of 402 amino acids with a molecular weight of about 43.5kDa. Amino acid sequence analysis revealed high sequence identity (84–93%) to known SAM-s proteins from Streptomyces species containing the conserved sequence motifs of SAM-s proteins, such as...