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SHIV deleted in two accessory genes, ΔvpuΔnef SHIV PPC , functioned well as a vaccine against later challenge with highly pathogenic SHIV KU , and it was able to reach the brain after oral inoculation of live virus. In this study, the proviral genome cloned into a plasmid was inoculated as DNA intracerebrally and spread systemically. Few regions of the brain had detectable proviral...
Use of the macaque model of human immunodeficiency virus (HIV) pathogenesis has shown that the accessory genes nef and vpu are important in the pathogenicity of simian immunodeficiency virus (SIV) and simian–human immunodeficiency virus (SHIV). We examined the ability of two nonpathogenic SHIVs, SHIV PPC and ΔvpuΔnefSHIV PPC , to gain pathogenicity by rapid serial passage in macaques...
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