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In March 2020, there were no treatment options for COVID‐19. Passive immune therapy including anti‐SARS‐CoV‐2 hyperimmune globulin (hIVIG) was a logical candidate for COVID‐19 therapeutic trials, given past success treating emerging pathogens with endogenous neutralizing antibodies. We established a plasma collection protocol for persons recovered from COVID‐19. To speed recruitment in the first U...
Many well‐known problems with two‐sided p‐values are due to their use in hypothesis tests, with ‘reject–accept’ conclusions about point null hypotheses. We present an alternative motivation for p‐value‐based tests, viewing them as assessments of only the sign of an underlying parameter, where we can conclude that the parameter is positive or negative, or simply say nothing either way. Our approach...
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