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Diabetic nephropathy (DN) is a common complication of diabetes mellitus which has a major impact on patient morbidity and mortality, and therefore a profound impact on the delivery of health care in this country. It affects more than one-third of patients with type I diabetes and an ever-increasing proportion of patients with type II diabetes, such that it is the single most common cause of end-stage...
A propagation model has been developed to simulate the corruption of wideband radio waveforms (such as radar chirps) as they pass through a non-homogeneous ionosphere. The ionosphere is modelled by a series of phase changing screens and a split-step Parabolic Equation method is used to describe the propagation of the complex electromagnetic field in planes normal to the propagation vector. Wideband...
We investigated the establishment of integrating transformation vectors in the genome ofDictyostelium discoideumto gain insight into the formation of the plasmid insertions and to investigate the conditions that determine the number of plasmid copies present in such insertions. Transformation vectors conferring resistance to neomycin and/or blasticidin were introduced into the cell as a calcium phosphate...
Transformation ofEscherichia coliwithDictyostelium discoideumgenomic DNA containing integrated shuttle vectors in multicopy, tandemly duplicated format resulted in the establishment of the linear plasmid molecules as circular monomeric replicons. The transformation efficiencies were comparable to those obtained with circular plasmid DNA and the recovered plasmids were free of deletions and rearrangements...
Summary form only given. Our recent studies of the soft x-rays produced from the intense irradiation of large atomic clusters (100-10,000 atoms per cluster) suggested that these clusters, which form in the adiabatic expansion of a gas jet into vacuum, may be a unique medium for high-order harmonic generation. We have studied the characteristics of the harmonic generation from these clusters and found...
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