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Introduction Sex hormones, especially estrogens, have been implicated in articular cartilage metabolism and the pathogenesis of postmenopausal osteoarthritis. The conversion by aromatase (CYP19A1) of androstenedione into estrone (E1) and of testosterone into 17β-estradiol (E2) plays a key role in the endogenous synthesis of estrogens in tissue. Methods We analyzed the expression of aromatase (CYP19A1)...
To analyse the hypothesis as to whether there is a functional relationship between human cationic amino acid transporters (hCATs, y + transporter, the main transporter of l-arginine and l-lysine) and human β-defensin (important components of immune function) production on the ocular surface, arginase and nitrate monoxide synthase (NOS), enzymes that compete for l-arginine, were inhibited by...
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