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There has been an increasing number of cyber-physical systems (CPSs) in the last decade. CPSs sometimes include wireless networks that incur delay and errors. In this paper, we have developed an integrated design approach to combine control system and faulttolerant wireless network design for an advanced, hightemperature, small, modular nuclear reactor (SMR). Our design approach is composed of two...
Molecule based devices may govern the advancement of futuristic logic and memory devices for the next generation computers. Molecules are strong candidate for becoming important device elements, because chemists can mass produce a variety of molecules with unique set of optical, magnetic, and charge transport characteristics. However, the biggest challenge is to connect two metal electrodes to molecule(s)...
The HPIV2 V protein inhibits type I interferon (IFN) induction and signaling. To manipulate the V protein, whose coding sequence overlaps that of the polymerase-associated phosphoprotein (P), without altering the P protein, we generated an HPIV2 virus in which P and V are expressed from separate genes (rHPIV2-P+V). rHPIV2-P+V replicated like HPIV2-WT in vitro and in non-human primates. HPIV2-P+V was...
In wild-type human parainfluenza virus type 2 (WT HPIV2), one gene (the P/V gene) encodes both the polymerase-associated phosphoprotein (P) and the accessory V protein. We generated a HPIV2 virus (rHPIV2-V ko ) in which the P/V gene encodes only the P protein to examine the role of V in replication in vivo and as a potential live attenuated virus vaccine. Preventing expression of V protein...
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