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The factors which regulate the properties of granulation tissue remain uncertain. The key cells in granulation tissue are fibroblasts and their role was investigated in rat skin excisional wounds.Full thickness wounds in 28 Hooded Lister rats were made and traced. On days 1 to 7, animals in groups of 4received colchicine 1 mg/kg subcutaneously, 4 h before being killed. Wound sections were stained...