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Coating of micrometer-sized particles of salbutamol sulphate or sodium chloride with the amino acid l-leucine in the gas phase is described. A novel method to synthesize core particles and coat them with l-leucine simultaneously was carried out in an aerosol flow reactor. The coating was prepared via temperature-induced heterogeneous nucleation of l-leucine vapor on the 0.6–1.0 µm core particles,...
Preparation of L-leucine nanoparticles by a process based on physical vapor deposition has been presented. In an aerosol flow reactor method, aqueous L-leucine droplets were first dried followed by the sublimation of L-leucine to produce vapor that upon vapor deposition resulted in L-leucine nanoparticles with size ranging from 40 to 200nm. Onset temperature for the sublimation of L-leucine at concentrations...
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