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Hypoxia-inducible factor 1 (HIF-1) is a dimeric transcription factor composed of HIF-1α and HIF-1β subunits that plays an essential role in mammalian O 2 homeostasis. InHif1a −/− knockout mice, complete deficiency of HIF-1α resulted in cardiac and vascular malformations and embryonic lethality at E10.5. Between E8.75 and E9.25 striking vascular regression and abnormal remodeling occurred...
Genetically based alcohol sensitivity may influence the severity of alcohol-related birth defects. To examine this question, measures of growth and survival were examined in offspring of the alcohol sensitive Long-Sleep (LS) and alcohol-resistant Short-Sleep (SS) mouse lines following prenatal ethanol exposure. Pregnant LS and SS mice received an ethanol dose of either 6 or 8 g/kg/day from days...
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