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Increasing evidence suggests that the metabolism of glutathione, an endogenous redox regulator, is abnormal in schizophrenia. Patients show a deficit in glutathione levels in the cerebrospinal fluid and prefrontal cortex and a reduction in gene expression of the glutathione synthesizing enzymes. We investigated whether such glutathione deficit altered synaptic transmission and plasticity in slices...
The dopamine D 3 receptor agonist PD 128907 decreased body temperature in the rat. The selective dopamine D 3 and D 4 receptor antagonists, A-437203 and L-745,870, respectively, did not prevent this effect. In contrast, PD 128907-induced hypothermia was antagonized by SCH 23390, a selective D 1 receptor antagonist, and by L-741,626, a selective D 2 receptor...
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