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Levels of tumor necrosis factor-α (TNF-α) are increased in the brain in Alzheimer's disease (AD). The TNF-α/TNF-R signaling pathways involve complex interactions between several proteins, including TNF-receptor-associated factor-2 (TRAF-2). We have examined the distribution and levels of TRAF-2 in AD and control brains and also whether single nucleotide polymorphisms (SNPs) in the TRAF-2 gene are...
The levels of pro-inflammatory cytokines, such as tumour necrosis factor-α (TNF-α), are increased in the brain in Alzheimer’s disease (AD). Most of the biological properties of TNF-α are mediated through its two receptors, tumour necrosis factor receptors I and II (TNF-RI and TNF-RII). We have used immunohistochemistry, Western blotting and real time-PCR (RT-PCR) on frontal (BA 6/24) and temporal...
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