The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
We have developed a novel genetic platform enabling high-throughput identification of genetic targets in embryonic stem cells (ESC) of the mouse (Mamm Genome 20: 11, 2009). We propose to utilize this platform to identify genes causing cryotoxicity. The method consists of mass screening of mutated populations of ESC. Mutated cells are then exposed to a near-lethal concentration of a cryogenic agent...