Search results for: Benedetta Bodini

Items from 1 to 17 out of 17 results

article

COVID‐19 vaccination hesitancy among people with chronic neurological disorders: A position paper

Martin Rakusa, Serefnur Öztürk, Elena Moro, Raimund Helbok, more

European Journal of Neurology > 29 > 8 > 2163 - 2172

Background and purpose Health risks associated with SARS‐CoV‐2 infection are undisputed. Moreover, the capability of vaccination to prevent symptomatic, severe, and fatal COVID‐19 is recognized. There is also early evidence that vaccination can reduce the chance for long COVID‐19. Nonetheless, the willingness to get vaccinated and receive booster shots remains subpar among people with neurologic...

article

Spontaneous remyelination in lesions protects the integrity of surrounding tissues over time in multiple sclerosis

Vito A. G. Ricigliano, Matteo Tonietto, Mariem Hamzaoui, Émilie Poirion, more

European Journal of Neurology > 29 > 6 > 1719 - 1729

Background and purpose Lesion remyelination preserves axonal integrity in animal models of multiple sclerosis (MS), but an in vivo demonstration of its protective effect on surrounding tissues in humans is lacking. Methods Nineteen persons with MS were enrolled in a cohort study and underwent two positron emission tomography (PET)/magnetic resonance imaging (MRI) scans 1–4 months apart. Voxelwise...

article

Lessons learned from people with neurological diseases at the time of COVID‐19: The EFNA‐EAN survey

Benedetta Bodini, Elena Moro, Joke Jaarsma, Elizabeth Cunningham, more

European Journal of Neurology > 29 > 1 > 318 - 323

Background and purpose The European Federation of Neurological Associations (EFNA), in partnership with the NeuroCOVID‐19 taskforce of the European Academy of Neurology (EAN), has investigated the impact of the first wave of the COVID‐19 pandemic on individuals with neurological diseases, as well as the hopes and fears of these patients about the post‐pandemic phase. Methods An EFNA‐EAN survey...

article

A plea for equitable global access to COVID‐19 diagnostics, vaccination and therapy: The NeuroCOVID‐19 Task Force of the European Academy of Neurology

Johann Sellner, Thomas M. Jenkins, Tim J. Oertzen, Claudio L. Bassetti, more

European Journal of Neurology > 28 > 11 > 3849 - 3855

Coronavirus disease 2019 (COVID‐19), a multi‐organ disease caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), continues to challenge health and care systems around the globe. The pandemic has disrupted acute neurology services and routine patient care and has impacted the clinical course in patients with chronic neurological disease. COVID‐19 appears to have exposed inequalities...

article

Primary prevention of COVID‐19: Advocacy for vaccination from a neurological perspective

Johann Sellner, Thomas M. Jenkins, Tim J. von Oertzen, Claudio L. Bassetti, more

European Journal of Neurology > 28 > 10 > 3226 - 3229

article

The European Academy of Neurology COVID‐19 registry (ENERGY): an international instrument for surveillance of neurological complications in patients with COVID‐19

Ettore Beghi, Raimund Helbok, Michael Crean, Sherry Hsiang‐Yi Chou, more

European Journal of Neurology > 28 > 10 > 3303 - 3323

The COVID‐19 pandemic is a global public health issue. Neurological complications have been reported in up to one‐third of affected cases, but their distribution varies significantly in terms of prevalence, incidence and phenotypical characteristics. Variability can be mostly explained by the differing sources of cases (hospital vs. community‐based), the accuracy of the diagnostic approach and the...

article

Exploring the heterogeneity of MS lesions using positron emission tomography: a reappraisal of their contribution to disability

Bruno Stankoff, Emilie Poirion, Matteo Tonietto, Benedetta Bodini

Brain Pathology > 28 > 5 > 723 - 734

The biological mechanisms driving disability worsening in multiple sclerosis (MS) are only partly understood. Monitoring changes in lesion load on MRI has a limited predictive value on the progression of clinical disability, and there is an essential need for novel imaging markers specific for the main candidate mechanisms underlying neurodegeneration which include failing myelin repair, innate immune...

article

Benzothiazole and stilbene derivatives as promising positron emission tomography myelin radiotracers for multiple sclerosis

Benedetta Bodini, Mattia Veronese, Federico Turkheimer, Bruno Stankoff

Annals of Neurology > 80 > 1 > 166 - 167

article

Dynamic Imaging of Individual Remyelination Profiles in Multiple Sclerosis

Benedetta Bodini, Mattia Veronese, Daniel García‐Lorenzo, Marco Battaglini, more

Annals of Neurology > 79 > 5 > 726 - 738

BackgroundQuantitative in vivo imaging of myelin loss and repair in patients with multiple sclerosis (MS) is essential to understand the pathogenesis of the disease and to evaluate promyelinating therapies. Selectively binding myelin in the central nervous system white matter, Pittsburgh compound B ([¹¹C]PiB) can be used as a positron emission tomography (PET) tracer to explore myelin dynamics in...

article

The neuronal component of gray matter damage in multiple sclerosis: A [¹¹C]flumazenil positron emission tomography study

Léorah Freeman, Daniel Garcia‐Lorenzo, Laure Bottin, Claire Leroy, more

Annals of Neurology > 78 > 4 > 554 - 567

ObjectiveUsing positron emission tomography (PET) with [¹¹C]flumazenil ([¹¹C]FMZ), an antagonist of the central benzodiazepine site located within the GABA_A receptor, we quantified and mapped neuronal damage in the gray matter (GM) of patients with multiple sclerosis (MS) at distinct disease stages. We investigated the relationship between neuronal damage and white matter (WM) lesions and evaluated...

article

Classification algorithms with multi-modal data fusion could accurately distinguish neuromyelitis optica from multiple sclerosis

Arman Eshaghi, Sadjad Riyahi-Alam, Roghayyeh Saeedi, Tina Roostaei, more

NeuroImage: Clinical > 2015 > 7 > C > 306-314

Neuromyelitis optica (NMO) exhibits substantial similarities to multiple sclerosis (MS) in clinical manifestations and imaging results and has long been considered a variant of MS. With the advent of a specific biomarker in NMO, known as anti-aquaporin 4, this assumption has changed; however, the differential diagnosis remains challenging and it is still not clear whether a combination of neuroimaging...

article

Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging

Olga Ciccarelli, Frederik Barkhof, Benedetta Bodini, Nicola De Stefano, more

The Lancet Neurology > 2014 > 13 > 8 > 807-822

The mechanisms underlying the pathogenesis of multiple sclerosis induce the changes that underpin relapse-associated and progressive disability. Disease mechanisms can be investigated in preclinical models and patients with multiple sclerosis by molecular and metabolic imaging techniques. Many insights have been gained from such imaging studies: persisting inflammation in the absence of a damaged...

article

Brain networks disconnection in early multiple sclerosis cognitive deficits: An anatomofunctional study

Céline Louapre, Vincent Perlbarg, Daniel García‐Lorenzo, Marika Urbanski, more

Human Brain Mapping > 35 > 9 > 4706 - 4717

Severe cognitive impairment involving multiple cognitive domains can occur early during the course of multiple sclerosis (MS). We investigated resting state functional connectivity changes in large‐scale brain networks and related structural damage underlying cognitive dysfunction in patients with early MS. Patients with relapsing MS (3–5 years disease duration) were prospectively assigned to two...

article

Temporal and spatial evolution of grey matter atrophy in primary progressive multiple sclerosis

Arman Eshaghi, Benedetta Bodini, Gerard R. Ridgway, Daniel García-Lorenzo, more

NeuroImage > 2014 > 86 > Complete > 257-264

Grey matter (GM) atrophy occurs early in primary progressive MS (PPMS), but it is unknown whether its progression involves different brain regions at different rates, as is seen in other neurodegenerative diseases. We aimed to investigate the temporal and regional evolution of GM volume loss over 5years and its relationship with disability progression in early PPMS.We studied 36 patients with PPMS...

article

A novel approach with “skeletonised MTR” measures tract‐specific microstructural changes in early primary‐progressive MS

Benedetta Bodini, Mara Cercignani, Ahmed Toosy, Nicola De Stefano, more

Human Brain Mapping > 35 > 2 > 723 - 733

We combined tract‐based spatial statistics (TBSS) and magnetization transfer (MT) imaging to assess white matter (WM) tract‐specific short‐term changes in early primary‐progressive multiple sclerosis (PPMS) and their relationships with clinical progression. Twenty‐one PPMS patients within 5 years from onset underwent MT and diffusion tensor imaging (DTI) at baseline and after 12 months. Patients'...

article

Corpus callosum damage predicts disability progression and cognitive dysfunction in primary‐progressive MS after five years

Benedetta Bodini, Mara Cercignani, Zhaleh Khaleeli, David H. Miller, more

Human Brain Mapping > 34 > 5 > 1163 - 1172

We aim to identify specific areas of white matter (WM) and grey matter (GM), which predict disability progression and cognitive dysfunction after five years in patients with primary‐progressive multiple sclerosis (PPMS). Thirty‐two patients with early PPMS were assessed at baseline and after five years on the Expanded Disability Status Scale (EDSS), and EDSS step‐changes were calculated. At year five,...

article

A cross-sectional, multicentre study of the therapeutic management of multiple sclerosis relapses in Italy

Pietro Annovazzi, Valentina Tomassini, Benedetta Bodini, Laura Boffa, more

Neurological Sciences > 2013 > 34 > 2 > 197-203

Despite the existence of therapeutic guidelines, management of multiple sclerosis relapse remains heterogeneous. Optimisation of relapse outcome demands an improved understanding of the neurologist’s therapeutic attitude towards relapse management, which is the aim of this study. Neurologists from 13 multiple sclerosis centres completed a questionnaire every time they assessed multiple sclerosis relapses...

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Keywords

MULTIPLE SCLEROSIS (6)
COVID‐19 (4)
SARS‐COV‐2 (3)
ADVOCACY (2)
NEUROLOGY (2)
PRIMARY‐PROGRESSIVE MULTIPLE SCLEROSIS (2)
REMYELINATION (2)
SURVEY (2)
TRACT‐BASED SPATIAL STATISTICS (2)
BRAIN ATROPHY (1)
CHRONIC DISORDERS (1)
CLINICAL PROGRESSION (1)
COGNITION (1)
COMPLICATIONS (1)
COMPUTATIONAL DIAGNOSIS (1)
CORTICOSTEROIDS (1)
DEFAULT MODE NETWORK (1)
DIFFERENTIAL DIAGNOSIS (1)
DISABILITY WORSENING (1)
DISPARITY (1)
DWI (1)
EAN (1)
EQUITABLE GLOBAL HEALTH (1)
INFECTIOUS DISEASE PREVENTION (1)
INNATE IMMUNE CELL (1)
LESION FILLING (1)
LONGITUDINAL ANALYSIS (1)
MAGNETIZATION TRANSFER IMAGING (1)
MANAGEMENT (1)
MEDICAL CARE (1)
MICROGLIA (1)
MRI (1)
MULTI-MODAL IMAGING (1)
NEURODEGENERATION (1)
NEUROLOGICAL DISEASES (1)
NEUROLOGICAL DISORDERS (1)
NEUROMYELITIS OPTICA (1)
NEUROPSYCHOLOGICAL ASSESSMENT (1)
OUTCOME (1)
PEOPLE WITH NEUROLOGICAL DISEASE (1)
PERSPECTIVE (1)
POSITRON EMISSION TOMOGRAPHY (1)
PRIMARY PREVENTION (1)
REGISTRY (1)
RELAPSE (1)
RESTING STATE (1)
TENSOR-BASED MORPHOMETRY (1)
VACCINATION (1)
VACCINE SKEPTICISM (1)
VOXEL-BASED MORPHOMETRY (1)
VOXEL‐BASED MORPHOMETRY (1)
WHITE MATTER LESIONS (1)
[11C]PIB‐PET (1)
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Wiley (13)
Elsevier (3)
Springer (1)

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Search results for: Benedetta Bodini

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