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Human papillomaviruses (HPV) 16 is a DNA virus encoding three oncogenes — E5, E6, and E7. The E6 and E7 proteins have well-established roles as inhibitors of tumor suppression, but the contribution of E5 to malignant transformation is controversial. Using spontaneously immortalized human keratinocytes (HaCaT cells), we demonstrate that expression of HPV16 E5 is necessary and sufficient for the formation...
Cell–cell fusion is an important biological and pathological event. There are limited techniques for studying both the process of cell–cell fusion and the fate of fused cells. We have developed a non-invasive assay for the temporal analysis of cell–cell fusion, quantification of fused cells, and isolation of fused cells. Briefly, cells are transfected with either the T7 bacteriophage RNA polymerase,...
Many nuclear-targeted proteins are transported through the nuclear pore complex (NPC) by the importin-α:β receptor. We now show that Npap60 (also called Nup50), a protein previously believed to be a structural component of the NPC, is a Ran binding protein and a cofactor for importin-α:β-mediated import. Npap60 is a tri-stable switch that alternates between binding modes. The C terminus binds importin-β...
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