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The early transcription unit 3 (E3) of adenoviruses (Ads) encodes immunomodulatory functions. We previously described a novel gene of 49K within the E3 region of Ad19a, an Ad of subgenus D that is similar to Ad8 and Ad37 causes epidemic keratoconjunctivitis (EKC). Interestingly, 49K was reported not to be present in Ad9 and Ad17, other subgenus D Ads not causing EKC. Therefore, we investigated whether...
Background. We have established that mucosal immunoglobulin A (IgA) production is highly dependent on cholecystokinin release and is markedly suppressed by glucocorticoids. The purpose of the present study was to examine the role of cholecystokinin on the functional responsiveness of the mucosal IgA system in glucocorticoid treated rats.Methods. A total of 24 Fischer rats were assigned to three groups...
The fiber and hexon genes of the immunological adenovirus (Ad) variant strains Ad9/Hx and Ad15/Hx, belonging to subgenus D, were sequenced and compared to the corresponding sequences of the prototypes Ad9 and Ad15. It was found that the variants possessed a novel and identical hemagglutinin as they could not be distinguished by hemagglutination-inhibition tests. These serological data were now confirmed...
The hexon genes of human adenovirus (AV) types 3, 16 (both subgenus B), and 4 (subgenus E) were sequenced and the nucleotide and predicted amino acid sequences were compared. We observed a high degree of homology between the three serotypes and thus could confirm the close evolutionary relationship of subgenera B and E which was previously inferred after comparing other genome regions. Employing the...
The fiber genes of human adenovirus types 8, 9, 15, and two genome types of intermediate adenovirus 15/H9, allbelonging to subgenus D, were sequenced and the nucleotide and predicted amino acid sequences compared. The analyzed peptide sequences were consistent with the structural domains described for other adenoviruses: an amino-terminal tail region, an intervening shaft region composed of eight...
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