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Arachidonic acid-derived eicosanoids (lipoxins and 15-epilipoxins) have a major role in resolution of inflammation. 15-epi-lipoxin A 4 (15-epi-LXA 4 ) is a lipid mediator with strong anti-inflammatory and inflammation-resolving effects. We examined the effect of pioglitazone therapy on plasma 15-epi-LXA 4 in patients with type 2 diabetes (T2DM).T2DM patients (Age = 56 ± 2 y,...