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Genomic characterization of pediatric acute lymphoblastic leukemia (ALL) has identified distinct patterns of genes and pathways altered in patients with well‐defined genetic aberrations. To extend the spectrum of known somatic variants in ALL, we performed whole genome and transcriptome sequencing of three B‐cell precursor patients, of which one carried the t(12;21)ETV6‐RUNX1 translocation and two...
Poly(A)-specific ribonuclease (PARN) is a homodimeric, processive, and cap-interacting 3′ exoribonuclease that efficiently degrades eukaryotic mRNA poly(A) tails. The crystal structure of a C-terminally truncated PARN in complex with m 7 GpppG reveals that, in one subunit, m 7 GpppG binds to a cavity formed by the RRM domain and the nuclease domain, whereas in the other subunit, it...
A transient approach has been applied to a system deactivating due to coke formation, in order to determine the kinetics for the main reaction. The method, which was used on a PtSn/Al 2 O 3 catalyst deactivated during propane dehydrogenation, consisted of runs in which the gas composition and temperature were changed in steps. By separating the deactivation from the main reaction kinetics,...
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