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We have previously shown that Bax translocation was crucial in TNFα or etoposide-induced apoptosis. Overexpression of Bax sensitized chronic myeloid leukemic K562 cells to etoposide-induced apoptosis. Treatment with TNF-related apoptosis-inducing ligand (TRAIL) induces a loss of mitochondrial membrane potential (ΔΨm), cytochrome c release from mitochondria, activation of caspases-8, -9, and -3, and...