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Rubiscolin-6 (Tyr-Pro-Leu-Asp-Leu-Phe) is a δ opioid peptide derived from the large subunit of spinach d-ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco). We previously reported that rubiscolin-6 had an analgesic effect and stimulated memory consolidation. Here we show that intraperitoneally (i.p.) or orally administered rubiscolin-6 has an anxiolytic effect at a dose of 10mg/kg or 100mg/kg,...
β-Lactotensin (His-Ile-Arg-Leu) is an ileum-contracting tetrapeptide isolated from bovine β-lactoglobulin. We previously reported that a neurotensin agonist β-lactotensin shows antinociceptive effect through neurotensin NT 2 receptor. We found that centrally or orally administered β-lactotensin at a dose of 60nmol/mouse or 300–500mg/kg, respectively, increased memory consolidation in the step-through-type...
Enterostatin (APGPR) is a pentapeptide released from its precursor protein, procolipase. We found for the first time that enterostatin has memory-enhancing activity. Enterostatin enhanced memory consolidation after central or oral administration at a dose of 10nmol/mouse or 300mg/kg, respectively, in a step-through type passive avoidance test in mice. The memory-enhancing activity of enterostatin...
In this study, we examined the antinociceptive effect of β-lactotensin, a neurotensin agonist that has been isolated from the chymotrypsin digest of β-lactoglobulin as an ileum-contracting peptide. β-Lactotensin showed naloxone-insensitive antinociceptive activity by the tail-pinch test after i.c.v. (200 nmol/mouse) or s.c. (300 mg/kg) administration in ddY mice. Tolerance was not developed to antinociception...
To study the structure-activity relationship of rubiscolins (YPLDLF and YPLDL), δ opioid peptides derived from the spinach Rubisco, we substituted the amino acid residues and evaluated their activities by mouse vas deferens (MVD) and guinea pig ileum (GPI) assays as well as receptor affinity. Replacement of Leu 3 with Ile and Met in rubiscolin-6 potentiated the δ opioid activity by about four...
We found that the sequences YPLDL and YPLDLF in the large subunit of spinach D-ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) met the structure YP-aliphatic amino acid which might have opioid activity. We then synthesized these peptides to test their opioid activity. The IC 50 of these peptides in mouse vas deferens assay were 51.0 μM and 24.4 μM, respectively, and those in...
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