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The transmembrane protease complex γ‐secretase is a key enzyme in Alzheimer disease pathogenesis as it liberates the neurotoxic amyloid β‐peptide (Aβ); however, the mechanism of regulation of its activity in various cell types and subcellular compartments is largely unknown. Several γ‐secretase inhibitors have been developed, but none have been released due to side‐effects that appear to arise from...
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