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PurposeTo assess the effects of ICA‐105665, an agonist of neuronal Kv7 potassium channels, on epileptiform EEG discharges, evoked by intermittent photic stimulation (IPS), the so‐called photoparoxysmal responses (PPRs) in patients with epilepsy.
MethodsMale and female patients aged 18–60 years with reproducible PPRs were eligible for enrollment. The study was conducted as a single‐blind, single‐dose,...
1192U90 was developed on the assumption that antagonism of 5-HT 2 receptors efficacy yields more potently than D 2 receptors against positive and negative symptoms of schizophrenia with minimal liability for extrapyramidal side effects (EPSs), and that 5-HT 1A agonism further reduces EPSs and provides anxiolytic and antidepressant activity. 1192U90 was submitted to four...
Binding of 3 H-spiperone and 3 H-raclopride to membranes of cells stably-transfected with a human dopamine D 2 receptor clone was investigated, as was that of 3 H-spiperone to those stably-transfected with a human D 4 receptor clone. 3 H-spiperone and 3 H-raclopride labeled the same number of sites in the D 2 receptor preparation. The...
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