Search results for: Mayumi Nishimura

Items from 1 to 20 out of 28 results

article

Ionizing radiation promotes, whereas calorie restriction suppresses, NASH and hepatocellular carcinoma in mice

Yi Shang, Takamitsu Morioka, Kazuhiro Daino, Takafumi Nakayama, more

International Journal of Cancer > 153 > 8 > 1529 - 1542

The pathological conditions of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NASH) are the major risk factors for hepatocellular carcinoma (HCC). Exposure to DNA‐damaging agents such as ionizing radiation is another risk factor for HCC; calorie restriction (CR), however, effectively delays the onset of radiation‐induced HCC. We investigated whether NASH is relevant to radiation‐induced...

article

Epigenetic dysregulation of key developmental genes in radiation‐induced rat mammary carcinomas

Kazuhiro Daino, Mayumi Nishimura, Tatsuhiko Imaoka, Masaru Takabatake, more

International Journal of Cancer > 143 > 2 > 343 - 354

With the increase in the number of long‐term cancer survivors worldwide, there is a growing concern about the risk of secondary cancers induced by radiotherapy. Epigenetic modifications of genes associated with carcinogenesis are attractive targets for the prevention of cancer owing to their reversible nature. To identify genes with possible changes in functionally relevant DNA methylation patterns...

chapter

Combined Effect of Ionizing Radiation and N-Ethyl-N-Nitrosourea on Mutation Induction and Lymphoma Development

Kazumi Yamauchi, Shizuko Kakinuma, Akifumi Nakata, Tatsuhiko Imaoka, more

Radiation Health Risk Sciences > Radiation Basic Life Sciences, Part 2 > 227-231

Carcinogenesis in humans is thought to result from exposure to numerous environmental factors. Little is known, however, about how these different factors work in combination to cause cancer. Mouse thymic lymphoma is a good model for research on radiation and chemical carcinogenesis. We examined here the occurrence of thymic lymphoma and mutation induction following exposure to both X-rays and N-ethyl-N-nitrosourea...

article

The effect of age at exposure on the inactivating mechanisms and relative contributions of key tumor suppressor genes in radiation-induced mouse T-cell lymphomas

Masaaki Sunaoshi, Yoshiko Amasaki, Shinobu Hirano-Sakairi, Benjamin J. Blyth, more

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis > 2015 > 779 > Complete > 58-67

Children are considered more sensitive to radiation-induced cancer than adults, yet any differences in genomic alterations associated with age-at-exposure and their underlying mechanisms remain unclear. We assessed genome-wide DNA copy number and mutation of key tumor suppressor genes in T-cell lymphomas arising after weekly irradiation of female B6C3F1 mice with 1.2Gy X-rays for 4 consecutive weeks...

article

Molecular characterization of cancer reveals interactions between ionizing radiation and chemicals on rat mammary carcinogenesis

Tatsuhiko Imaoka, Mayumi Nishimura, Kazutaka Doi, Shusuke Tani, more

International Journal of Cancer > 134 > 7 > 1529 - 1538

Although various mechanisms have been inferred for combinatorial actions of multiple carcinogens, these mechanisms have not been well demonstrated in experimental carcinogenesis models. We evaluated mammary carcinogenesis initiated by combined exposure to various doses of radiation and chemical carcinogens. Female rats at 7 weeks of age were γ‐irradiated (0.2–2 Gy) and/or exposed to 1‐methyl‐1‐nitrosourea...

article

Uranium dynamics and developmental sensitivity in rat kidney

Shino Homma‐Takeda, Toshiaki Kokubo, Yasuko Terada, Kyoko Suzuki, more

Journal of Applied Toxicology > 33 > 7 > 685 - 694

Renal toxicity is the principal health concern after uranium exposure. Children are particularly vulnerable to uranium exposure; with contact with depleted uranium in war zones or groundwater contamination the most likely exposure scenarios. To investigate renal sensitivity to uranium exposure during development, we examined uranium distribution and uranium‐induced apoptosis in the kidneys of neonate...

article

Co-operative effects of thoracic X-ray irradiation and N-nitrosobis(2-hydroxypropyl) amine administration on lung tumorigenesis in neonatal, juvenile and adult Wistar rats

Ken-ichi Iwata, Yutaka Yamada, Akifumi Nakata, Yoichi Oghiso, more

Toxicology and Applied Pharmacology > 2013 > 267 > 3 > 266-275

Assessment of risks associated with childhood exposure to ionizing radiation when combined with chemical carcinogens is of great importance. We studied the age-dependence of the effect of combined exposure to ionizing radiation (IR) and a chemical carcinogen on lung carcinogenesis. Female 1-, 5-, and 22-week-old Wistar rats were locally irradiated on the thorax with X-rays (3.18Gy) and/or were injected...

article

Influence of Age on the Relative Biological Effectiveness of Carbon Ion Radiation for Induction of Rat Mammary Carcinoma

Tatsuhiko Imaoka, Mayumi Nishimura, Kazuhiro Daino, Toshiaki Kokubo, more

International Journal of Radiation Oncology, Biology, Physics > 2013 > 85 > 4 > 1134-1140

The risk of developing secondary cancer after radiotherapy, especially after treatment of childhood cancers, remains a matter of concern. The high biological effects of carbon-ion radiation have enabled powerful radiotherapy, yet the approach is commonly restricted to the treatment of adults. Susceptibility of the fetus to particle radiation–induced cancer is also unclear. The present study is aimed...

article

Establishment and characterization of a novel ovarian clear cell adenocarcinoma cell line, TU-OC-1, with a mutation in the PIK3CA gene

Hiroaki Itamochi, Misaki Kato, Mayumi Nishimura, Nao Oumi, more

Human Cell > 2013 > 26 > 3 > 121-127

A new cell line of human ovarian clear cell adenocarcinoma (CCC), TU-OC-1, was established and characterized. The cells showed a polygonal-shaped morphology and grew in monolayers without contact inhibition and were arranged like a jigsaw puzzle. The chromosome numbers ranged from 64 to 90. A low rate of proliferation was observed, similar to other CCC cell lines tested (OVTOKO, RMG-I, and OVAS),...

article

Ikaros is a critical target during simultaneous exposure to X‐rays and N‐ethyl‐N‐nitrosourea in mouse T‐cell lymphomagenesis

Shinobu Hirano, Shizuko Kakinuma, Yoshiko Amasaki, Mayumi Nishimura, more

International Journal of Cancer > 132 > 2 > 259 - 268

Cancer risk associated with radiation exposure is considered the result of concurrent exposure to other natural and manmade carcinogens. Available data on the molecular characteristics of cancer after simultaneous exposure to radiation and chemicals are insufficient. In our study, we used a mouse thymic lymphoma (TL) model that was synergistically induced by simultaneous exposure to X‐rays and N‐ethyl‐...

article

Combined exposure to X-irradiation followed by N-ethyl-N-nitrosourea treatment alters the frequency and spectrum of Ikaros point mutations in murine T-cell lymphoma

Shizuko Kakinuma, Mayumi Nishimura, Yoshiko Amasaki, Mayumi Takada, more

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis > 2012 > 737 > 1-2 > 43-50

Ionizing radiation is a well-known carcinogen, but its potency may be influenced by other environmental carcinogens, which is of practical importance in the assessment of risk. Data are scarce, however, on the combined effect of radiation with other environmental carcinogens and the underlying mechanisms involved. We studied the mode and mechanism of the carcinogenic effect of radiation in combination...

article

Interleukin‐9 receptor gene is transcriptionally regulated by nucleolin in T‐Cell lymphoma cells

Yi Shang, Shizuko Kakinuma, Mayumi Nishimura, Yoshiro Kobayashi, more

Molecular Carcinogenesis > 51 > 8 > 619 - 627

Interleukin‐9 (IL‐9) is a multifunctional cytokine that not only has roles in immune and inflammatory responses but also is involved in growth‐promoting and anti‐apoptotic activities in multiple transformed cell lines, which suggests a potential role in tumorigenesis. Over‐expression of the receptor of IL‐9 (IL‐9R) occurs in several types of human leukemias and in radiation‐induced mouse T‐cell lymphoma...

article

Establishment and characterization of a novel ovarian serous adenocarcinoma cell line, TU-OS-4, that overexpresses EGFR and HER2

Hiroaki Itamochi, Misaki Kato, Mayumi Nishimura, Tetsuro Oishi, more

Human Cell > 2012 > 25 > 4 > 111-115

A new line of human ovarian serous adenocarcinoma cells, TU-OS-4, was established and characterized. The cells showed a short, spindle-shaped morphology and grew in monolayers without contact inhibition while forming an arrangement resembling a jigsaw puzzle. Chromosome numbers ranged from 55 to 73. The proliferation rate was lower than other serous adenocarcinoma cell lines tested (KF, SHIN-3, and...

article

Pre‐ and postpubertal irradiation induces mammary cancers with distinct expression of hormone receptors, ErbB ligands, and developmental genes in rats

Tatsuhiko Imaoka, Mayumi Nishimura, Daisuke Iizuka, Yukiko Nishimura, more

Molecular Carcinogenesis > 50 > 7 > 539 - 552

Childhood exposure to carcinogens renders a higher risk of breast cancer. The molecular mechanisms underlying cancer development after such exposure are not, however, well understood. Here we examined how the mechanism of cancer development relates to the age at exposure to ionizing radiation (IR) or the carcinogen 1‐methyl‐1‐nitrosourea (MNU). Pre‐ and postpubertal (3‐ and 7‐wk‐old, respectively)...

article

Aloe vera oral administration accelerates acute radiation-delayed wound healing by stimulating transforming growth factor-β and fibroblast growth factor production

Ayman Atiba, Mayumi Nishimura, Shizuko Kakinuma, Takeshi Hiraoka, more

The American Journal of Surgery > 2011 > 201 > 6 > 809-818

Delayed wound healing is a significant clinical problem in patients who have had previous irradiation. This study investigated the effectiveness of Aloe vera (Av) on acute radiation-delayed wound healing.The effect of Av was studied in radiation-exposed rats compared with radiation-only and control rats. Skin wounds were excised on the back of rats after 3 days of local radiation. Wound size was measured...

article

Complicated biallelic inactivation of Pten in radiation-induced mouse thymic lymphomas

Yu Yamaguchi, Takashi Takabatake, Shizuko Kakinuma, Yoshiko Amasaki, more

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis > 2010 > 686 > 1-2 > 30-38

Inactivation of the phosphatase and tensin homolog gene (Pten) occurs via multiple tissue-dependent mechanisms including epigenetic silencing, point mutations, insertions, and deletions. Although frequent loss of heterozygosity around the Pten locus and plausible involvement of epigenetic silencing have been reported in radiation-induced thymic lymphomas, the proportion of lymphomas with inactivated...

article

Age dependence of radiation‐induced renal cell carcinomas in an Eker rat model

Toshiaki Kokubo, Shizuko Kakinuma, Toshiyuki Kobayashi, Fumiko Watanabe, more

Cancer Science > 101 > 3 > 616 - 623

(Cancer Sci 2010; 101: 616–623) Exposure to carcinogens early in life may contribute to cancer development later in life. The amount of radiation exposure children experience during medical procedures has been increasing, so it is important to evaluate the radiation risk of cancer in developing organs. Toward this goal, we assessed the risk of developing renal cell carcinoma using Eker rats as a kidney...

article

Preliminary study on potential of the jPET-D4 human brain scanner for small animal imaging

Taiga Yamaya, Eiji Yoshida, Chie Toramatsu, Mayumi Nishimura, more

Annals of Nuclear Medicine > 2009 > 23 > 2 > 183-190

Objective One trend in positron emission tomography (PET) instrumentation over the last decade has been the development of scanners dedicated to small animals such as rats and mice. Thicker crystals, which are necessary to obtain higher sensitivity, result in degraded spatial resolution in the peripheral field-of-view (FOV) owing to the parallax error. On the other hand, we are developing the jPET-D4,...

article

Differential effects of low- and high-dose X-rays on N-ethyl-N-nitrosourea-induced mutagenesis in thymocytes of B6C3F1 gpt-delta mice

Kazumi Yamauchi, Shizuko Kakinuma, Satomi Sudo, Seiji Kito, more

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis > 2008 > 640 > 1-2 > 27-37

Carcinogenesis in humans is thought to result from exposure to numerous environmental factors. Little is known, however, about how these different factors work in combination to cause cancer. Because thymic lymphoma is a good model of research for combined exposure, we examined the occurrence of mutations in thymic DNA following exposure of B6C3F1 gpt-delta mice to both ionizing radiation and N-ethyl-N-nitrosourea...

article

Distinct structural abnormalities of chromosomes 11 and 12 associated with loss of heterozygosity in X-ray–induced mouse thymic lymphomas

Mitsuaki A. Yoshida, Akifumi Nakata, Miho Akiyama, Shizuko Kakinuma, more

Cancer Genetics and Cytogenetics > 2007 > 179 > 1 > 1-10

Loss of heterozygosity (LOH) plays an important role in leukemogenesis via inactivation of tumor suppressor genes. Recent studies have demonstrated that mouse thymic lymphomas (TL), a suitable model for the mechanistic study of human acute lymphoblastic leukemia, show frequent LOH on chromosomes 4 (p15/p16), 11 (Ikaros), 12 (Bcl11b), 19 (Pten), and X. To date, however, little data are available regarding...

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INFONA - science communication portal

Search results for: Mayumi Nishimura

Ionizing radiation promotes, whereas calorie restriction suppresses, NASH and hepatocellular carcinoma in mice

Epigenetic dysregulation of key developmental genes in radiation‐induced rat mammary carcinomas

Combined Effect of Ionizing Radiation and N-Ethyl-N-Nitrosourea on Mutation Induction and Lymphoma Development

The effect of age at exposure on the inactivating mechanisms and relative contributions of key tumor suppressor genes in radiation-induced mouse T-cell lymphomas

Molecular characterization of cancer reveals interactions between ionizing radiation and chemicals on rat mammary carcinogenesis

Uranium dynamics and developmental sensitivity in rat kidney

Co-operative effects of thoracic X-ray irradiation and N-nitrosobis(2-hydroxypropyl) amine administration on lung tumorigenesis in neonatal, juvenile and adult Wistar rats

Influence of Age on the Relative Biological Effectiveness of Carbon Ion Radiation for Induction of Rat Mammary Carcinoma

Establishment and characterization of a novel ovarian clear cell adenocarcinoma cell line, TU-OC-1, with a mutation in the PIK3CA gene

Ikaros is a critical target during simultaneous exposure to X‐rays and N‐ethyl‐N‐nitrosourea in mouse T‐cell lymphomagenesis

Combined exposure to X-irradiation followed by N-ethyl-N-nitrosourea treatment alters the frequency and spectrum of Ikaros point mutations in murine T-cell lymphoma

Interleukin‐9 receptor gene is transcriptionally regulated by nucleolin in T‐Cell lymphoma cells

Establishment and characterization of a novel ovarian serous adenocarcinoma cell line, TU-OS-4, that overexpresses EGFR and HER2

Pre‐ and postpubertal irradiation induces mammary cancers with distinct expression of hormone receptors, ErbB ligands, and developmental genes in rats

Aloe vera oral administration accelerates acute radiation-delayed wound healing by stimulating transforming growth factor-β and fibroblast growth factor production

Complicated biallelic inactivation of Pten in radiation-induced mouse thymic lymphomas

Age dependence of radiation‐induced renal cell carcinomas in an Eker rat model

Preliminary study on potential of the jPET-D4 human brain scanner for small animal imaging

Differential effects of low- and high-dose X-rays on N-ethyl-N-nitrosourea-induced mutagenesis in thymocytes of B6C3F1 gpt-delta mice

Distinct structural abnormalities of chromosomes 11 and 12 associated with loss of heterozygosity in X-ray–induced mouse thymic lymphomas

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