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Coronary artery calcification (CAC) is a heritable and definitive morphologic marker of atherosclerosis that strongly predicts risk for future cardiovascular events. To search for genes involved in CAC, we used an integrative transcriptomic, genomic, and protein expression strategy by using next-generation DNA sequencing in the discovery phase with follow-up studies using traditional molecular biology...
DNAX‐activation protein 12 (DAP12), a transmembrane adapter, plays a major role in transducing activation signals in natural killer cells and various myeloid cells. Quantitative RT‐PCR detected in normal mouse eyes considerable levels of DAP12 and multiple DAP12‐coupled receptors, in particular TREM‐1, Clec5a and SIRPb1. The role of DAP12 and its receptors in experimental autoimmune diseases has been...
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