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Hyperactivation of the RAS−RAF signaling pathway in colorectal tumors is associated with metastasis and poor outcomes of patients. Little is known about how RAS−RAF signaling is turned off once activated. We investigated how the pH domain and leucine-rich repeat protein phosphatases (PHLPPs) control RAS−RAF signaling and colorectal cancer (CRC) development.We used co-immunoprecipitation assays to...
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