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The role of the Frank–Starling mechanism in the regulation of cardiac systolic function in the ischemic failing heart was examined in conscious dogs. Left ventricular (LV) dimension, pressure and systolic function were assessed using surgically implanted instrumentations and non-invasive echocardiogram. Heart failure was induced by daily intra-coronary injections of microspheres for 3–4 weeks via...
Background: Catecholamines and many inotropic agents increase cardiac contractility but also cause excessive myocardial O 2 consumption (MVO 2 ). We determined if the novel Na + channel enhancer LY341311, which increases myocardial contractility independent of [beta ] receptors, can produce significant cardiac inotropic effects compared with dobutamine but at lower oxygen cost...
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