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TRPM8 is now best known as a cold- and menthol-activated channel implicated in thermosensation. TRPM8 is specifically expressed in a subset of pain- and temperature-sensing neuron. TRPM8 plays a major role in the sensation of cold and cooling substances. TRPM8 is a potential new target for the treatment of painful conditions. Thus, TRPM8 antagonists represent a new, novel and potentially useful treatment...