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Background Preclinical and clinical evidence supports the concept of bidirectional brain-gut microbiome interactions. We aimed to determine if subgroups of irritable bowel syndrome (IBS) subjects can be identified based on differences in gut microbial composition, and if there are correlations between gut microbial measures and structural brain signatures in IBS. Methods Behavioral measures, stool...
Maternal infection can alter the intrauterine environment, placing the developing fetus at risk. Serious infections of the mother or the fetus can cause severe problems or even miscarriage. The more common and seemingly benign infections, such as influenza, do not appear associated with such severe outcomes. However, recent work has shown that maternal inflammation associated with any infection has...
The observation that maternal infection increases the risk for schizophrenia in the offspring suggests that the maternal immune system plays a key role in the etiology of schizophrenia. In a mouse model, maternal immune activation (MIA) by injection of poly(I:C) yields adult offspring that display abnormalities in a variety of behaviors relevant to schizophrenia. As abnormalities in the hippocampus...
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