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What is known and objective
Polypharmacy is associated with an increased risk of adverse drug reactions (ADRs) and drug interactions, decreased adherence to medication and increased medical cost. Recently, polypharmacy has become a major problem in medical care in Japan as a result of the increase in the ageing population. The purpose of this study was to investigate the current situation of polypharmacy...
The accurate analysis of trace components in complex biological matrices requires the use of reliable internal standards. For liquid chromatography/mass spectrometry analysis, the stable isotope-labeled analogues of the analyte molecules are the most appropriate internal standards. In this paper the synthesis of the 3- and 21-monosulfates of allo-tetrahydrocorticosteroids labeled with four or five...
The 3- and 21-monosulfates of pentadeuterated 5β-tetrahydrocorticosteroides were synthesized, starting from cortisol and 11-deoxycotisol. The principal reactions used were (1) perdeuteration of the methylene groups adjacent to the 3-oxo group of 17,20:20,21-bismethylendioxy-5β-3-ketosteroids with NaOD in CH 3 OD followed by stereoselective reduction with NaBD 4 , (2) sulfation of hydroxy...
This report presents an Othello Solver based on a 32-bit original soft-core Multiple Instruction stream, Multiple Data stream (MIMD) processor array targeting a single field programmable gate array (FPGA), Cyclone II (EP2C70D896C6N), on a DE2 Development and Education Board (Altera Corp.). The solver can execute a move-checking operation, a disc flipping operation, a move selection operation, an evaluation...
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