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Le gène NOD2/CARD15 code pour une protéine qui appartient à la famille des récepteurs de l’immunité innée. Elle porte 4 domaines. Un domaine fait de répétition de zones riches en leucine permet l’interaction avec des composants bactériens dont le lipopolysaccharide (LPS). Un domaine liant les nucléotides (NBD) permet l’oligomérisation de la protéine. Enfin, deux domaines Caspase recruitment domain...