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Virus‐like particles (VLPs) displaying foreign antigens have become an important tool in vaccination including the induction of immune responses against self‐antigens. Claudin 6 (CLDN6) has been identified as tumor‐associated antigen and is therefore a potential target for tumor vaccination strategies. However, as tetra‐membrane spanning protein its incorporation into VLPs while preserving a native...
Retroviral vectors have yet not been tested for their potential as vaccines despite their frequent utilization in gene therapy allowing for highly efficient gene transfer into a number of cell types and their suitability for large-scale production in biotechnology. To investigate MLV-based vectors suitability for inducing immune response against HIV-1-antigens, we generated a MLV(HIV-1) pseudotype...
Retroviral vectors derived from amphotropic murine leukemia viruses (MLV) mediate gene transfer into almost all human cells and are thus not suitable for in vivo applications in gene therapy in which cell-specific gene delivery is required. We and others recently reported the generation of MLV-derived vectors pseudotyped by variants of the envelope glycoproteins (Env) of human immunodeficiency virus...
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