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Three members of the ERG potassium channel family have been described (ERG1–3 or Kv 11.1–3). ERG1 is by far the best characterized subtype and it constitutes the molecular component of the cardiac I Kr current. All three channel subtypes are expressed in neurons but their function remains unclear. The lack of functional information is at least partly due to the lack of specific pharmacological...
This work demonstrates cell swelling as a new regulatory mechanism for the cloned hyperpolarization-activated, cyclic nucleotide-gated channel 2 (HCN2). HCN2 channels were coexpressed with aquaporin1 in Xenopus laevis oocytes and currents were monitored using a two-electrode voltage-clamp. HCN2 channels were activated by hyperpolarization to −100mV and the currents were measured before and during...
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