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Three simple and sensitive spectrophotometric methods for the determination of tamoxifen citrate have been developed. They are based on the formation of an ion-association complex between the drug and a dye, Erioglaucine A, which is extractable into chloroform and has an absorption maximum at 625 nm (method A), oxidation with excess potassium permanganate and the determination of unconsumed permanganate...
The acid--base equilibria of 2-furoic acid hydrazide (FAH) and adipic acid dihydrazide (AADH) were investigated by pH measurements in water--dimethylformamide (10:60, v/v) and water--dioxane (10:60, v/v). The protonation constants were estimated by MINIQUAD75 which employs a non-linear least squares method based on the Marquardt algorithm. The variation in log K M1 (log β 0 ...
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