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Macrophages are involved in many essential immune functions. Their role in cell‐autonomous innate immunity is reinforced by interferon‐γ (IFN‐γ), which is mainly secreted by proliferating type 1 T helper cells and natural killer cells. Previously, we showed that IFN‐γ activates autophagy via p38 mitogen‐activated protein kinase (p38 MAPK), but the biological importance of this signalling pathway has...
Macrophages are engaged in many essential host functions, and their activation is a dynamic process that results in diverse functional outcomes such as the potentiation of bactericidal activity and production of chemokines, cytokines, and mediators that coordinate the inflammatory response. This pro-inflammatory response is bimodal, comprising a “prime” event, classically through interferon-γ (IFN-γ),...
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