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Seasonal hyporesponsiveness and other immune system variations were observed in female B6C3F1 mice during routine screening tests for immunomodulation. In a retrospective assessment, 4 years of data from over 1200 naive, vehicle, and immunosuppressed (cyclophosphamide-treated) control mice were compiled and analyzed for uniformity and significant circannual pattern of immune response. Endpoints included...
Previous studies by our group have demonstrated that in vitro exposure to δ-opioid receptor agonists results in a significant immunostimulation, whereas in vitro exposure to non-peptidic δ-opioid receptor antagonists results in significant suppression of various immune functions. The present study assessed potential immunomodulation by the peptidic δ-opioid receptor antagonists TIPP, D-TIPP, and ICI...
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